Beta-Cyclodextrin
■ Chemical Description
--Beta-cyclodextrin (abbr. β-CD)
■ CAS No. 7585-39-9
■ Molecular and Structural Formula C42H72O36
■ Characteristics
--White crystal or powder, odorless smell and taste sweet;
--Slightly soluble in water,insoluble in methanol, ethanol, acetone or aether;
■ Specification
No |
Tests |
Specification |
||
CP2010 |
BP2009(A) |
USP31(NF26) |
||
1 |
Specific rotation |
+159°~+164° |
+160°~+164° |
+160°~+164° |
2 |
PH |
5.0~8.0 |
5.0~8.0 |
|
3 |
Clarity and color of solution |
+ |
+ |
+ |
4 |
Loss on drying % |
≤14.0 |
≤16.0 |
≤14.0 |
5 |
Chloride % |
≤0.018 |
|
|
6 |
Residue on ignition % |
≤0.1 |
≤0.1 |
≤0.1 |
7 |
Sugar % |
≤1.0 |
≤0.2 |
≤1.0 |
8 |
Heavy Metal ppm |
≤10 |
≤10 |
≤5 |
9 |
Determination % |
96.0%~102.0 |
98.0%~101.0 |
98.0%~101.0 |
10 |
Absorbing impurities |
+ |
+ |
|
11 |
Related Substances |
|
+ |
|
12 |
Residual Solvents |
|
+ |
|
13 |
Microbial Limit |
+ |
+ |
+ |
■ Application
--Used to increase the stability of the drug, improve the bioavailability drugs, change medication water-soluble, remove drug peculiar smell, reduce the side effects of drugs;
■ Packaging and Storage
--Packed in 25, 50 kg fiber or plastic drum, inner lined with PE bags;
--Stored in dry place at room temperature;
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